Key result
Type-1 diabetic patients with autonomic neuropathy showed overall hyposensitivity to combined mechanical, thermal, and electrical stimulations in the oesophagus and duodenum (P=0.02).
Why the study?
Are there differences in gut sensitivity and referred pain areas between type-1 diabetic patients with autonomic neuropathy and healthy controls?
Case-Control (n=24)
Are there differences in gut sensitivity and referred pain areas between type-1 diabetic patients with autonomic neuropathy and healthy controls?
p-value: p=0.02
Type-1 diabetic patients with autonomic neuropathy exhibit generalized gut hyposensitivity and increased somatic referred pain areas, suggesting both peripheral and central neuronal changes.
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May complicate visceral pain assessment in type-1 diabetes; leaves open peripheral-central mechanisms of gut hyposensitivity.
Frøkjær et al. (2007) conducted a case-control in Type-1 diabetes with autonomic neuropathy (n=24). Type-1 diabetes with autonomic neuropathy vs. Healthy subjects was evaluated on Overall sensitivity to the combination of mechanical, thermal and electrical stimulations in the oesophagus and duodenum (p=0.02). Type-1 diabetic patients with autonomic neuropathy showed overall hyposensitivity to combined mechanical, thermal, and electrical stimulations in the oesophagus and duodenum (P=0.02).
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