The Therapeutic Effectiveness and Potency of Digilanid in the Treatment of Congestive Heart Failure

Article1 May 1941THE THERAPEUTIC EFFECTIVENESS AND POTENCY OF DIGILANID IN THE TREATMENT OF CONGESTIVE HEART FAILUREROBERT C. BATTERMAN, M.D., DELAVAN V. HOLMAN, M.D., ARTHUR C. DEGRAFF, M.D., F.A.C.P.ROBERT C. BATTERMAN, M.D., DELAVAN V. HOLMAN, M.D., ARTHUR C. DEGRAFF, M.D., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-14-11-2058 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptOver a period of years, evidence has been accumulating attesting to limitations of the bio-assay for digitalis bodies. Preparations of the same potency with regard to their ability to produce death in a cat or frog will vary markedly in their therapeutic potency as applied to man. Outstanding examples of this discrepancy are the purified digitalis glycosides, digitoxin, (Merck1or "digitaline nativelle"2) and Verodigen (Gitalin)3, 4and other members of the digitalis group such as g-strophanthin (Ouabain)5and Urginin.6This marked difference among various digitalis bodies has resulted in confusion. To substitute one preparation for another and still maintain the...Bibliography1. EGGLESTON C: Digitalis dosage, Arch. Int. Med., 1915, xvi, 1. CrossrefGoogle Scholar2. GOLDKWITCATTELL HNTM: Studies on purified digitalis glucosides. I. Potency and dosage of "digitaline nativelle" by oral administration in man, Jr. Pharm. and Exper. Therap., 1940, lxix, 177. Google Scholar3. STROUDLIVINGSTONBROWNVANDER VEERGRIFFITH WDAEAWJBGC: Use of Verodigen (a digitalis glucoside) in cardiovascular disease; its biological assay and pharmacological action, ANN. INT. MED., 1934, viii, 710. Google Scholar4. 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(d) JANSON, P.: Klinische und ambulante Erfahrungen mit Digilanid, dem neuen Digitalispräparat Sandoz, Therap. d. Gegenw., 1934, lxxv, 45. (e) BERTHEAU, H.: Klinische Erfahrungen mit Digilanid, Deutsche med. Wchnschr., 1934, lx, 1504. (f) NIETEN, L.: Ueber Digilanid—Therapie bei Herzkranken, Therap. d. Gegenw., 1935, lxxvi, 253. (g) BAUKE, E. E.: Klinische Digilanidstudien bei intestinaler und parenteraler Verabreichung, Deutche med. Wchnschr., 1935, lxi, 371. (h) ROTH, O.: Ueber Herztherapie unter specieller Berücksichtigung des Digilanid, Schweiz. med. Wchnschr., 1935, lxv, 741. (i) ROLLER, D.: Die Indikationen und Anwendung von Digilanid, Therap. d. Gegenw., 1937, lxxviii, 162. (j) VON SACHS, E.: Klinische Erfahrungen mit Digilanid bei enteraler und parenteraler Zufuhr, Zentralbl. f. inn. Med., 1937, lviii, 849. (k) ROHR, K., and WUHRMANN, F.: Vier Jahre klinische Erfahrungen mit Digilanid unter besonderer Berücksichtigung einiger therapeutischen Eigenschaften, Schweiz. med. Wchnschr., 1938, lxviii, 261. (l) JUNET, R., and BIANCHI, M.: Étude clinique d'un nouveau digitalique: le digilanide, Rev. méd. de la Suisse Rom., 1939, lix, 139. (m) OETTEL, H.: Digitalis lanata. Klinisch geshen: Tatsachen und Wertung, Med. Klin., 1939, xxxv, 1628. Google Scholar9. BATTERMANROSEDEGRAFF RCOAAC: The combined use of ouabain and digitalis in the treatment of congestive heart failure, Am. Heart Jr., 1940, xx, 443. CrossrefGoogle Scholar10. Nomenclature and Criteria for Diagnosis of Diseases of the Heart, Ed. 4, 1939, New York Heart Association, New York. Google Scholar11. DEGRAFFNADLERBATTERMAN ACJERC: A study of the diuretic effect of mercupurin in man, Am. Jr. Med. Sci., 1936, cxci, 526. CrossrefGoogle Scholar12. ADAMSGREGG WL: Clinical comparison of the crystalline glucosides of digitalis lanata (digilanid) and the powdered leaf of digitalis, Am. Heart Jr., 1940, xix, 576. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, N. Y.*Received for publication October 28, 1940.From the Department of Therapeutics, New York University College of Medicine and the Third (New York University) Medical Division of Bellevue Hospital.†We are indebted to Sandoz Chemical Works, Inc. for the generous supply of material and other aid in connection with this investigation. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe Therapeutic Range of Gitalin (Amorphous) Compared with Other Digitalis PreparationsStudies with gitalin (amorphous) for the treatment of patients with congestive heart failureComparative study on the use of the purified digitalis glycosides, digoxin, digitoxin, and lanatoside C, for the management of ambulatory patients with congestive heart failureClinical studies on digoxin, a purified digitalis glycosideRecent Advances in Digitalis Therapy with Particular Attention to the Use of Pure Glycosides 1 May 1941Volume 14, Issue 11Page: 2058-2072KeywordsGlycosidesHeart failureHospital medicine ePublished: 1 December 2008 Issue Published: 1 May 1941 PDF downloadLoading ...