Placental transfer of chlorpromazine. Case report.

Case Report A 33-year-old mother had a history of puerperal depression after the birth of her first child 6 years earlier. She presented with symptoms of a schizoaffective disorder, mainly depressive, at 36 weeks of her second pregnancy which was otherwise normal. She was sedated heavily with chlorpromazine, initially 350 mg. daily, rising to a maximum of 1800 mg. during the 5th day of treatment. She was also given occasional doses of sodium amytal, haloperidol, amitryptiline hydrochloride, diperodon hydrochloride (Akineton), and lithium carbonate. After one week of treatment, she developed albuminuria and hypertension and, after spontaneous onset of labour, delivered normally a boy weighing 3-8 kg. She had by then received a total dose of 8000 mg. chlorpromazine in 10 days, 6300 mg. having been given in the last 6 days.