Key result
A low EQ-5D-5L index was associated with a significantly greater risk of mortality compared to a high index in patients with HFpEF (HR 1.81; 95% CI 1.12-2.92; P=0.002).
Why the study?
Evidence on the prognostic utility of generic quality of life scores is scarce, particularly in patients with HFpEF.
Does a lower EQ-5D-5L index at discharge predict increased mortality in patients with HFpEF?
Observational (n=864)
Yes
Does a lower EQ-5D-5L index at discharge predict increased mortality in patients with HFpEF?
Hazard Ratio: 1.81 (95% CI 1.12–2.92)
Absolute Event Rate: 34% vs 14%
p-value: p=0.002
The generic EQ-5D-5L quality of life score assessed at discharge is a useful tool for risk stratification and predicting mortality in patients with HFpEF.
May support EQ-5D-5L for mortality risk stratification in HFpEF; leaves open prospective validation before routine use.
AIMS: Patient reported outcomes (PROs) are gradually being incorporated into daily practice to assess individual health-related quality of life (QOL). However, despite accumulating evidence of the prognostic utility of heart failure (HF)-specific QOL indices, evidence on the generic QOL score is scarce, especially in patients with HF with preserved ejection fraction (HFpEF). METHODS AND RESULTS: Patient data were extracted from the Prospective mUlticenteR obServational stUdy of patIenTs with Heart Failure with Preserved Ejection Fraction (PURSUIT HFpEF) study. EuroQol 5 dimensions 5-level (EQ-5D-5L) data were obtained at discharge to evaluate patients' health-related QOL. The study population (n = 864) was divided into tertiles based on their EQ-5D-5L index as follows: low EQ-5D-5L 0.038-0.664 (n = 287), middle EQ-5D-5L 0.665-0.867 (n = 293), and high EQ-5D-5L 0.871-1.000 (n = 284). A total of 206 patients died over a mean follow-up period of 2.0 ± 1.2 years. Kaplan-Meier analysis revealed that the risk of mortality increased with the tertile of the EQ-5D-5L index (34% vs. 23% vs. 14%, P < 0.001). Cox multivariable analysis revealed that patients with EQ-5D-5L index in the low and middle tertiles had a significantly greater risk of mortality than those with EQ-5D-5L index in the high tertile [low EQ-5D-5L: adjusted hazard ratio (HR): 1.81 (1.12-2.92), P = 0.002, middle EQ-5D-5L: adjusted HR 1.91 (1.21-3.03), P = 0.006]. Among the dimensions of EQ-5D-5L, mobility (P = 0.014), self-care (P = 0.023) and usual activities (P = 0.008) were significant factors associated with all-cause mortality after multivariable adjustment. CONCLUSIONS: EQ-5D-5L is useful tool for risk stratification in patients with HFpEF.
No takes yet. Share an insight, caveat, or question.
Seo et al. (2022) conducted an observational in Heart failure with preserved ejection fraction (HFpEF) (n=864). Low EQ-5D-5L index vs. High EQ-5D-5L index was evaluated on Mortality (HR 1.81, 95% CI 1.12-2.92, p=0.002). A low EQ-5D-5L index was associated with a significantly greater risk of mortality compared to a high index in patients with HFpEF (HR 1.81; 95% CI 1.12-2.92; P=0.002).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: