Evaluation of the HFA-PEFF Score: Results from the Prospective DIAST-CHF Cohort

Figure 1. Cumulative overall mortality. Low score: score values 0 and 1; intermediate score: score values 2–4; high score: score values 5 and 6 in the HFA‐PEFF algorithm.

Figure 2. Six‐minute walking distance in all three groups at baseline and at 10‐year follow‐up. Low score: score values 0 and 1; intermediate score: score values 2–4; high score: score values 5 and 6 in the HFA‐PEFF algorithm. (A) Walk distance at baseline. (B) Walk distance at 10‐year follow‐up for the three groups. Results (average ± standard deviation): at baseline: low score 588 ± 83; median score 558 ± 108; high score 537 ± 93. At 10‐year follow‐up: low score 555 ± 76; median score 50 6 ± 116; high score 473 ± 126. Overall P value for changes over time: P < 0.001. Overall P value for differences between the groups at 10‐year follow‐up: P = 0.001. Low risk vs. median risk at 10‐year follow‐up: P = 0.006. Low risk vs. high risk: P = < 0.001. Median risk vs. high risk: P = 0.051.

Figure 3. Risk factors associated with high score values. BP, blood pressure. Contribution of specific risk factors to the HFA‐PEFF score value if present. Female sex [0.29, 95% CI (0.16, 0.42)], that is, the presence of female sex is associated with a 0.29 points contribution to the HFA‐PEFF score value. Obesity [0.25 (0.07, 0.43)], arterial hypertension [0.61 (0.44, 0.78)], coronary heart disease [0.41 (0.24, 0.58)], anaemia [0.66 (0.43, 0.89)], systolic blood pressure [0.10 (0.07, 0.14) per 10 mmHg], and heart rate [per 10/min, −0.15 (−0.20, −0.09)].