July 5, 2006Circulation
Plasma Phospholipid Trans Fatty Acids, Fatal Ischemic Heart Disease, and Sudden Cardiac Death in Older Adults
Key result
Higher levels of plasma phospholipid trans-18:2 fatty acids were associated with increased risk of fatal IHD (OR 1.68; 95% CI 1.21-2.33), while higher trans-18:1 levels were associated with lower risk.
Why the study?
Are different classes of plasma phospholipid trans fatty acids associated with the risk of fatal ischemic heart disease and sudden cardiac death in older adults?
Population
428 older adults from the Cardiovascular Health Study
Comparison
Higher levels of plasma phospholipid trans-18:2… vs Lower levels of plasma phospholipid trans-18:2…
Design
Case-control
Follow-up
Cases identified between 1992 and 1998
Authors
Discussion
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Member takes
Implication
Class-specific trans fatty acid associations with fatal IHD should not yet change practice; leaves open divergent effects needing prospective confirmation.
Study Design
Type
Case-Control (n=428)
Structured PICO
Are different classes of plasma phospholipid trans fatty acids associated with the risk of fatal ischemic heart disease and sudden cardiac death in older adults?
P
Population
428 older adults (214 cases of fatal ischemic heart disease and 214 matched controls) from the Cardiovascular Health Study.
E
Exposure
Higher levels of plasma phospholipid trans-18:2 and trans-18:1 fatty acids
C
Comparator
Lower levels of plasma phospholipid trans-18:2 and trans-18:1 fatty acids
O
Outcome
Fatal ischemic heart disease (fatal myocardial infarction and coronary heart disease death)hard clinical
Main Result
Odds Ratio: 1.68 (95% CI 1.21–2.33)
Higher levels of trans-18:2 fatty acids are associated with increased risk of fatal IHD and sudden cardiac death, whereas higher trans-18:1 levels are associated with lower risk, suggesting different trans fatty acid classes have divergent cardiovascular effects.
Cite This Study
Lemaître et al. (2006) conducted a case-control in Fatal ischemic heart disease and sudden cardiac death (n=428). Plasma phospholipid trans-18:2 fatty acids vs. Lower levels was evaluated on Fatal ischemic heart disease (IHD) (OR 1.68, 95% CI 1.21 to 2.33). Higher levels of plasma phospholipid trans-18:2 fatty acids were associated with increased risk of fatal IHD (OR 1.68; 95% CI 1.21-2.33), while higher trans-18:1 levels were associated with lower risk.