Progressive ECG changes before the onset of atrial flutter in adult congenital heart disease patients

Altered CD18 leucocyte integrin expression and adhesive function in patients with an acute coronary syndromeThe adhesion of leucocytes to vascular endothelium is fundamental to the pathogenesis of atherosclerosis and the acute coronary syndromes.The CD11b/CD18 receptor is particularly important in this process.This molecule is expressed on both neutrophils and monocytes.In common with other integrin receptors it consists of and subunits (CD11b and CD18, respectively), which allow binding of leucocytes to the endothelial surface. 1 The aims of our study were: (1) to compare the expression of CD11b and CD18 on peripheral neutrophils and monocytes in patients with an acute coronary syndrome, patients with stable coronary artery disease, and healthy controls; and (2) to assess any functional change in neutrophil adhesion in the acute coronary syndrome.