Why the study?
Does dimenhydrinate infusion unmask Brugada syndrome ECG patterns in asymptomatic patients?
Does dimenhydrinate infusion unmask Brugada syndrome ECG patterns in asymptomatic patients?
Dimenhydrinate, a common first-generation antihistamine, can unmask asymptomatic Brugada syndrome on ECG.
Dimenhydrinate may unmask Brugada ECG patterns; this single case leaves open any need for screening or avoidance.
Typical ECG of that described for Brugada syndrome was elicited in a patient diagnosed with labyrinthopathy during infusion of dimenhydrinate, a first-generation antihistamine usually used to treat motion sickness. Although the patient had no history of syncope or palpitations, and there was no family history of cardiac disease or sudden death, the ECG abnormality was reproduced later with intravenous flecainide, and an asymptomatic Brugada syndrome was diagnosed.
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Pastor et al. (2001) studied this question.
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