Key result
Depletion of La autoantigen by siRNA or inhibition by a dominant-negative mutant caused a dramatic reduction in poliovirus and HCV IRES function and virus yield.
Population
In vivo and in vitro models of poliovirus and hepatitis C virus (HCV) translation
Design
Preclinical
Authors
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La autoantigen may be an antiviral target for HCV and poliovirus; animal data leave open clinical translation.
The La autoantigen is necessary for optimal IRES-dependent translation of poliovirus and HCV RNAs by stimulating 40S ribosomal subunit binding.
Costa‐Mattioli et al. (2004) studied Poliovirus and Hepatitis C virus translation. La autoantigen depletion (siRNA) or inhibition (LaDN) vs. Control siRNA or empty vector was evaluated on Poliovirus IRES function and virus yield. Depletion of La autoantigen by siRNA or inhibition by a dominant-negative mutant caused a dramatic reduction in poliovirus and HCV IRES function and virus yield.
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