Key result
Tyrosine kinase inhibitors can alter thyroid hormone regulation and induce hypothyroidism, requiring regular assessment of thyroid function tests before and during treatment.
Why the study?
Do tyrosine kinase inhibitors affect thyroid function tests and induce hypothyroidism in patients with haematological and solid tumours?
Do tyrosine kinase inhibitors affect thyroid function tests and induce hypothyroidism in patients with haematological and solid tumours?
Tyrosine kinase inhibitors can induce hypothyroidism, highlighting the need for regular assessment of thyroid function tests before and during treatment to improve patient quality of life.
Answers are grounded in this paper and cite their sources.
May warrant thyroid monitoring with TKIs; leaves open precise risk estimates and optimal protocols from prospective trials.
Tyrosine kinase inhibitors (TKI) belong to new molecular multi-targeted therapies that are approved for the treatment of haematological and solid tumours. They interact with a large variety of protein tyrosine kinases involved in oncogenesis. In 2005, the first case of hypothyroidism was described and since then, some data have been published and have confirmed that TKI can affect the thyroid function tests (TFT). This review analyses the present clinical and fundamental findings about the effects of TKI on the thyroid function. Various hypotheses have been proposed to explain the effect of TKI on the thyroid function but those are mainly based on clinical observations. Moreover, it appears that TKI could alter the thyroid hormone regulation by mechanisms that are specific to each molecule. The present propositions for the management of TKI-induced hypothyroidism suggest that we assess the TFT of the patients regularly before and during the treatment by TKI. Thus, a better approach of patients with TKI-induced hypothyroidism could improve their quality of life.
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Illouz et al. (2008) conducted a review in Haematological and solid tumours. Tyrosine kinase inhibitors (TKI) was evaluated on Modifications of thyroid function tests and hypothyroidism. Tyrosine kinase inhibitors can alter thyroid hormone regulation and induce hypothyroidism, requiring regular assessment of thyroid function tests before and during treatment.
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