Why the study?
Does changing from metoprolol to pindolol improve peripheral vasospasm in men experiencing symptoms during beta-blocker therapy?
Does changing from metoprolol to pindolol improve peripheral vasospasm in men experiencing symptoms during beta-blocker therapy?
Vasospastic symptoms during beta-blocker therapy may occur in predisposed individuals regardless of the specific beta-blocker used, as switching from metoprolol to pindolol did not improve symptoms.
Answers are grounded in this paper and cite their sources.
Switching beta-blockers may not relieve vasospasm in susceptible patients; case report leaves open class effects on peripheral circulation.
Ten men reported vasospastic symptoms in their hands during metoprolol treatment. They had no signs of occlusive arterial disease. The temperature reaction to local cooling was measured and no improvement was found after changing to pindolol. Vasospastic symptoms during beta-receptor blockade may arise in predisposed individuals irrespective of the type of beta-receptor antagonist used.
No takes yet. Share an insight, caveat, or question.
Eliasson et al. (1982) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: