Key result
DHRS11 and LRKK2 were identified as programmed cell death-associated hub genes with effective diagnostic value for heart failure.
Why the study?
Heart failure is an important global public health problem where programmed cell death plays a crucial pathologic role, motivating identification of PCD-associated hub genes to improve diagnosis and treatment.
DHRS11 and LRKK2 were identified as key programmed cell death-associated hub genes in heart failure, providing potential new biomarkers for diagnosis and insights into molecular mechanisms.
AIMS: Heart failure (HF) is an important public health problem worldwide, and programmed cell death (PCD) plays a crucial role in its pathologic process. This study aims to identify the hub genes associated with HF through PCD in order to better understand the pathogenesis of HF and improve its diagnosis and treatment. METHODS AND RESULTS: The gene expression dataset of HF was obtained from the GEO database. Bioinformatics and machine learning algorithms were utilized to screen the HF key genes and PCD-related HF hub genes, and an HF diagnostic model was constructed on this. Functional enrichment analysis clarified the gene ontology and signalling pathways of HF. The immune infiltration analysis of HF was performed to explore the expression levels of immune cells in each hub gene. Through bioinformatics analysis, 95 HF key genes were obtained. Functional enrichment analysis showed that they were mainly involved in inflammation, immunomodulation and other mechanisms. DHRS11 and LRKK2 were identified as PCD-associated HF hub genes by machine learning algorithms. The hub genes were confirmed as significant biomarkers of HF in the training and validation datasets, and their constructed nomogram had effective diagnostic value. Immune infiltration analysis showed significant immune imbalance of T-cell populations, monocytes and macrophages M2 in HF. CONCLUSIONS: In this study, DHRS11 and LRKK2 were identified as hub genes. HF diagnostic model construction and immune infiltration analyses were performed, which provided new ideas for the molecular mechanisms of HF development and treatment.
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Yuan et al. (2025) studied Heart failure. Programmed cell death-related genes was evaluated on Identification of PCD-associated HF hub genes. DHRS11 and LRKK2 were identified as programmed cell death-associated hub genes with effective diagnostic value for heart failure.
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