Key result
Low-grade inflammation in youth with newly-diagnosed T2DM was significantly correlated with arterial stiffness parameters, including CF-PWV (r=0.34) and AIx (r=0.33) (all p<0.01).
Why the study?
Does low-grade inflammation correlate with increased arterial stiffness in Chinese youth and adolescents with newly-diagnosed T2DM?
Cross-Sectional (n=98)
Does low-grade inflammation correlate with increased arterial stiffness in Chinese youth and adolescents with newly-diagnosed T2DM?
p-value: p=<0.01
Low-grade inflammation is independently associated with increased arterial stiffness in youth and adolescents with newly-diagnosed T2DM, indicating an early adverse cardiovascular risk profile.
May signal early CV risk in youth with T2DM; leaves open causal role and need for prospective studies.
OBJECTIVE: To investigate the relationship between low-grade inflammation (LI) and increased arterial stiffness in Chinese youth and adolescents with newly-diagnosed type 2 diabetes mellitus (T2DM). METHODS: Ninety-eight subjects aged 10 to 24 years with newly-diagnosed T2DM were investigated for findings of general inflammation. Anthropometric measurements were taken. Data related to arterial stiffness [brachial artery distensibility (Branch D), augmentation index (AIx), carotid-femoral pulse wave velocity (CF-PWV)] were collected. The subjects were divided into a non-LI group (NLI, n=42) and a LI group (n=56) according to their high-sensitivity C-reactive protein (Hs-CRP) levels. RESULTS: There were no significant differences in age and gender between the LI group and the NLI group. CF-PWV and AIx values of the LI group were higher than those of the NLI group (p<0.01), while Branch D values were lower in the LI group (p<0.01). Branch D, CF-PWV, and AIx values correlated significantly with Hs-CRP overall (r=-0.32, 0.34, 0.33, all p<0.01). Multivariate models revealed that in either group (LI or NLI), Hs-CRP, as a continuous variable, was an independent determinant of arterial stiffness parameters even after adjusting for other risk factors. CONCLUSION: Newly-diagnosed T2DM youth and adolescents with LI present a more adverse cardiovascular disease risk profile and stiffer arteries. Hs-CRP levels correlated with arterial stiffness parameters and constituted an independent determinant of arterial stiffness.
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Li et al. (2015) conducted a cross-sectional in newly-diagnosed type 2 diabetes mellitus (n=98). Low-grade inflammation (elevated Hs-CRP) vs. Non-low-grade inflammation was evaluated on Arterial stiffness parameters (Branch D, AIx, CF-PWV) (p=<0.01). Low-grade inflammation in youth with newly-diagnosed T2DM was significantly correlated with arterial stiffness parameters, including CF-PWV (r=0.34) and AIx (r=0.33) (all p<0.01).
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