Key result
The SMAD2 rs11082639 SNP was significantly associated with an increased risk of metabolic syndrome (OR 1.66) in a Taiwanese population.
Why the study?
Are SNPs in TGF-beta signaling pathway genes associated with metabolic syndrome in a Taiwanese population?
Observational (n=3,000)
Yes
Are SNPs in TGF-beta signaling pathway genes associated with metabolic syndrome in a Taiwanese population?
Odds Ratio: 1.66 (95% CI 1.32–2.08)
p-value: p=1.4 x 10^-5
Genetic variants in the TGF-beta signaling pathway, specifically SMAD2 rs11082639 and TGFBR2 rs3773651, are significantly associated with metabolic syndrome in a Taiwanese population.
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Hypothesis-generating in cross-sectional data; leaves open SMAD2 role in metabolic syndrome beyond this Taiwanese cohort.
Lin et al. (2017) conducted an observational in Metabolic syndrome (n=3,000). SMAD2 rs11082639 SNP vs. Reference genotype was evaluated on Metabolic syndrome (OR 1.66, 95% CI 1.32-2.08, p=1.4 x 10^-5). The SMAD2 rs11082639 SNP was significantly associated with an increased risk of metabolic syndrome (OR 1.66) in a Taiwanese population.
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