Demonstrates extravascular shunting (countercurrent exchange) of oxygen in the intestinal mucosal vascular loops of cats at rest, which is abolished during vasodilation or vasoconstriction.
May indicate resting countercurrent oxygen shunting in intestinal mucosa; leaves open relevance to human gut perfusion.
Kampp, M., O. Lundgren and N. J. Nilsson. Extravascular shunting of oxygen in the small intestine of the cat. Acta physiol. scand. 1968. 72. 396–403. At “resting” intestinal blood flow the venous appearance time of intra-arterially injected red cells labelled with methemoglobin exceeded by 1–2 sec that of oxygen administered in an identical manner. This observation is taken to indicate an extravascular shunting (countercurrent exchange) of oxygen between the ascending and descending limbs of the mucosal vascular loops located mainly in the villi. During vasodilatation induced by isopropylnoradrenaline or vasoconstriction induced by stimulation of the regional sympathetic fibres (4 imp/sec) no difference in venous appearance time between red cells and oxygen could be demonstrated. The physiological significance of the findings of the present study is discussed.
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Kampp et al. (1968) studied this question.
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