Key result
Initiation of amiodarone in patients with structural heart disease and AF concomitantly treated with beta-blockers and digitalis was associated with a 25% incidence of ventricular arrhythmia.
Why the study?
Does amiodarone loading increase the risk of pro-arrhythmia in patients with atrial fibrillation on concomitant rate-control medication?
Population
63 consecutive patients with atrial fibrillation, mean age 64+/-10.3 years, 49 males.
Design
Cohort
Authors
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May warrant caution with amiodarone initiation in this population; leaves open need for prospective confirmation of proarrhythmic risk.
Cohort (n=63)
Does amiodarone loading increase the risk of pro-arrhythmia in patients with atrial fibrillation on concomitant rate-control medication?
Initiation of amiodarone in patients with structural heart disease and AF who are on concomitant beta-blockers and digitalis may carry an increased risk of pro-arrhythmia.
Schrickel et al. (2006) conducted a cohort in Atrial fibrillation (n=63). Amiodarone loading with concomitant beta-blocker and digitalis therapy was evaluated on Clinically relevant, polymorphic ventricular tachyarrhythmia. Initiation of amiodarone in patients with structural heart disease and AF concomitantly treated with beta-blockers and digitalis was associated with a 25% incidence of ventricular arrhythmia.
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