Key result
Amiodarone loading combined with beta-blocker and digitalis therapy was associated with early Torsade de pointes tachycardia in 3 patients with structural heart disease and atrial fibrillation.
Why the study?
Does amiodarone loading combined with beta-blockers and digitalis cause Torsade de pointes in patients with structural heart disease and atrial fibrillation?
Population
3 patients with structural heart disease and tachyarrhythmic atrial fibrillation.
Design
Case_series
Follow-up
up to 48 hours
Authors
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May signal heightened TdP risk with this combination in SHD and AF; hypothesis-generating and requires confirmation.
Case Report (n=3)
Does amiodarone loading combined with beta-blockers and digitalis cause Torsade de pointes in patients with structural heart disease and atrial fibrillation?
Amiodarone loading combined with beta-blockers and digitalis may increase the risk of Torsade de pointes in patients with structural heart disease and atrial fibrillation.
Schrickel et al. (2006) conducted a case report in Structural heart disease and atrial fibrillation (n=3). Amiodarone, beta-blockers, and digitalis was evaluated on Torsade de pointes tachycardia (Tdp). Amiodarone loading combined with beta-blocker and digitalis therapy was associated with early Torsade de pointes tachycardia in 3 patients with structural heart disease and atrial fibrillation.
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