Short-term, low-dose oral amiodarone can induce torsade de pointes even in the absence of predisposing factors.
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Clinicians should consider TdP risk even with low-dose oral amiodarone; case reports leave incidence and monitoring needs open.
Although amiodarone appears to have few pro-arrhythmic effects, torsade de pointes (TdP) has been observed during long-term drug administration, usually in conjunction with electrolyte disturbances, a change in drug dosage, or concomitant drug therapy. We report two cases of amiodarone-induced TdP shortly after administration of a low dose of oral amiodarone, in the absence of predisposing factors.
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Lim et al. (2006) studied this question.
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