Why the study?
Does the use of arithmetic mean versus geometric mean reference prothrombin time affect the accuracy and precision of INR determinations?
Population
Reference populations in three laboratory settings (evaluated via probabilistic model and bootstrap analysis)
Comparison
Arithmetic mean reference prothrombin time (PT) vs Geometric mean reference prothrombin time (PT)
Design
Other
Authors
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Arithmetic mean use may bias INR toward over-anticoagulation; leaves open whether geometric means are required for INR precision in routine labs.
Does the use of arithmetic mean versus geometric mean reference prothrombin time affect the accuracy and precision of INR determinations?
Laboratories must carefully determine the geometric mean reference prothrombin time to avoid significant biases in INR determinations that could lead to inappropriate clinical actions.
Critchfield et al. (1994) studied this question.
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