Key result
Propofol provided better hemodynamics, shorter mean seizure duration (22.56 vs 28.42 seconds, p<0.05), and quicker recovery compared to thiopentone during modified electroconvulsive therapy.
Why the study?
Does propofol improve hemodynamic stability compared to thiopentone in adult psychiatric patients undergoing modified electroconvulsive therapy?
Population
100 adult psychiatric patients undergoing modified electroconvulsive therapy.
Comparison
Propofol 1.5 mg/kg IV as an induction agent… vs Thiopentone 4 mg/kg IV as an induction agent…
Design
RCT, randomly divided in to two groups, single blinded
Follow-up
15 minutes post-procedure and recovery period
Authors
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Propofol warrants first-line consideration for modified ECT induction; this RCT confirms its hemodynamic and recovery advantages over thiopentone.
RCT (n=100)
Single-blind
Randomized
No
Does propofol improve hemodynamic stability compared to thiopentone in adult psychiatric patients undergoing modified electroconvulsive therapy?
Absolute Event Rate: 22.56% vs 28.42%
p-value: p=<0.05
Propofol provides superior hemodynamic stability and faster recovery compared to thiopentone when used as an induction agent for modified electroconvulsive therapy.
Benhur Premendran (2012) conducted an RCT in Psychiatric conditions requiring modified electroconvulsive therapy (n=100). Propofol vs. Thiopentone (4 mg/kg) was evaluated on Mean seizure duration (seconds) (p=<0.05). Propofol provided better hemodynamics, shorter mean seizure duration (22.56 vs 28.42 seconds, p<0.05), and quicker recovery compared to thiopentone during modified electroconvulsive therapy.
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