Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 13, 2007ViewOpen Access

The Picornavirus Avian Encephalomyelitis Virus Possesses a Hepatitis C Virus-Like Internal Ribosome Entry Site Element

View Full Paper
Ask AI
Bookmark
Share

Key result

The avian encephalomyelitis virus genome contains a hepatitis C virus-like internal ribosome entry site that functions efficiently in vitro and in mammalian cells.

Population

In vitro translation reactions (rabbit reticulocyte lysate) and mammalian cells (293 or HTK-143 cells)

Comparison

Avian encephalomyelitis virus 5' untranslated… vs EMCV IRES, HAV IRES, HCV IRES, PTV-1 IRES, or no…

Design

Preclinical

Authors

MBMehran BakhsheshRazi Vaccine and Serum Research InstituteEGElisabetta GroppelliSt George's, University of LondonMWM. M. WillcocksUniversity of Surrey

Discussion

Loading...

Member takes

Implication

AEV IRES functions in mammalian cells; leaves open reassessment of its hepatovirus classification pending further validation.

Structured PICO

P
Population
In vitro translation reactions (rabbit reticulocyte lysate) and mammalian cells (293 or HTK-143 cells)
E
Exposure
Avian encephalomyelitis virus (AEV) 5' untranslated region (UTR) sequences
C
Comparator
EMCV IRES, HAV IRES, HCV IRES, PTV-1 IRES, or no IRES
O
Outcome
IRES activity (measured by translation of reporter genes CAT and fLUC)surrogate

The discovery of an HCV-like IRES element in AEV suggests its classification within the hepatovirus genus may need reassessment.

Cite This Study

Bakhshesh et al. (2007) studied Avian encephalomyelitis virus (AEV). Mutational and functional analysis of AEV IRES vs. HAV IRES, HCV IRES, PTV-1 IRES was evaluated on IRES function and secondary structure. The avian encephalomyelitis virus genome contains a hepatitis C virus-like internal ribosome entry site that functions efficiently in vitro and in mammalian cells.

synapsesocial.com/papers/6a95bcad829b131aaf4f0c18https://doi.org/10.1128/jvi.01957-07
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 131 Translation Initiation on Picornavirus RNA2000 · 24 citations
  2. 2Functional Analyses of RNA Structures Shared between the Internal Ribosome Entry Sites of Hepatitis C Virus and the Picornavirus Porcine Teschovirus 1 Talfan2006 · 58 citations
  3. 35 Translation Initiation by Viral Internal Ribosome Entry Sites2007 · 74 citations
  4. 4Unique Characteristics of a Picornavirus Internal Ribosome Entry Site from the Porcine Teschovirus-1 Talfan2002 · 43 citations
  5. 5Proteins surrounding hairpin IIIe of the hepatitis C virus internal ribosome entry site on the human 40S ribosomal subunit2006 · 49 citations