January 13, 2006Journal of VirologyOpen Access

Functional Analyses of RNA Structures Shared between the Internal Ribosome Entry Sites of Hepatitis C Virus and the Picornavirus Porcine Teschovirus 1 Talfan

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Population

Internal ribosome entry site (IRES) elements of porcine teschovirus 1 (PTV-1) and hepatitis C virus (HCV)

Design

Preclinical

Authors

LCLouisa S. ChardQueen Mary University of London YKYoshihiro KakuNational Institute of Infectious Diseases BJBarbara B. JonesUniversity of Missouri

Discussion

Member takes

Implication

PTV-1 IRES functions independently of eIF4A; leaves open whether similarities to HCV IRES inform antiviral strategies.

Structured PICO

Population

Internal ribosome entry site (IRES) elements of porcine teschovirus 1 (PTV-1) and hepatitis C virus (HCV)

Intervention

Mutagenesis and functional assays (including dominant negative mutant form of eIF4A)

Outcome

Functional activity and validation of secondary-structure model featuressurrogate

The study identifies structural and functional similarities between the IRES elements of PTV-1 and HCV, which may help define critical features of this IRES type.

Cite This Study

Chard et al. (2006) studied this question.

synapsesocial.com/papers/6a8ea616e3420198dacd6d08 https://doi.org/10.1128/jvi.80.3.1271-1279.2006

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Functional Analyses of RNA Structures Shared between the Internal Ribosome Entry Sites of Hepatitis C Virus and the Picornavirus Porcine Teschovirus 1 Talfan

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Functional Analyses of RNA Structures Shared between the Internal Ribosome Entry Sites of Hepatitis C Virus and the Picornavirus Porcine Teschovirus 1 Talfan

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider