Key result
The porcine teschovirus-1 Talfan RNA contains a unique internal ribosome entry site (IRES) that is relatively short, lacks a significant polypyrimidine tract, and functions efficiently in vitro.
Population
Porcine teschovirus-1 (PTV) Talfan RNA and BHK cells
Comparison
Expression of enterovirus 2A protease vs Other picornavirus IRES elements
Design
Preclinical
Authors
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Expands picornavirus IRES diversity; leaves open structural validation and in vivo roles.
The PTV IRES represents a new class of picornavirus IRES element with unique properties, including being relatively short and lacking a significant polypyrimidine tract.
Kaku et al. (2002) studied this question. The porcine teschovirus-1 Talfan RNA contains a unique internal ribosome entry site (IRES) that is relatively short, lacks a significant polypyrimidine tract, and functions efficiently in vitro.
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