Key result
Initiation of antihypertensive treatment had no significant effect on cerebral blood flow in older adults (SMD 0.08; 95% CI -0.07 to 0.22; P=0.31).
Why the study?
In older age, the benefits of antihypertensive treatment become less evident with greater risk, particularly concerning potential compromise of cerebral blood flow.
Does initiation of antihypertensive treatment reduce cerebral blood flow in older adults with hypertension or cognitive impairment?
Comparison
After vs before initiating antihypertensive treatment
Design
Systematic review and random-effects meta-analysis
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AHT initiation poses no CBF risk in older adults; confirms safety and supports treatment without perfusion concerns.
Meta-Analysis (n=1,306)
Does initiation of antihypertensive treatment reduce cerebral blood flow in older adults with hypertension or cognitive impairment?
Standardized Mean Difference: 0.08 (95% CI -0.07–0.22)
p-value: p=0.31
Antihypertensive treatment initiation does not appear to have a harmful effect on cerebral blood flow in older adults, suggesting concerns over CBF should not preclude hypertension treatment.
A 2022 study conducted a meta-analysis in Hypertension or cognitive impairment (n=1,306). Antihypertensive treatment vs. Baseline (before treatment) was evaluated on Cerebral blood flow (SMD 0.08, 95% CI -0.07 to 0.22, p=0.31). Initiation of antihypertensive treatment had no significant effect on cerebral blood flow in older adults (SMD 0.08; 95% CI -0.07 to 0.22; P=0.31).
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