Association of Calcium Channel Blocker Use and Pregnancy-Associated Plasma Protein-A Among Older Adults With Hypertension: Results From the ilSIRENTE Study
Key result
Calcium channel blocker use was associated with significantly lower PAPP-A levels compared to nonuse among older adults with hypertension (1.58 vs 1.86 mIU/L; p=0.03).
Why the study?
Does calcium channel blocker use reduce PAPP-A levels in older adults with hypertension?
Population
314 older adults (≥80 years) with hypertension from the ilSIRENTE study, mean age 85.6, 66% women.
Comparison
Calcium channel blocker (CCB) use vs Non-use of CCB
Design
Cross-sectional
Authors
Discussion
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Implication
Lower PAPP-A with calcium channel blocker use in older hypertensives is hypothesis-generating; leaves open cardiovascular protection and requires prospective trials.
Study Design
Type
Cross-Sectional (n=314)
Structured PICO
Does calcium channel blocker use reduce PAPP-A levels in older adults with hypertension?
P
Population
314 older adults aged 80 years or older with hypertension.
E
Exposure
Calcium channel blocker (CCB) use
C
Comparator
Non-use of CCB
O
Outcome
Pregnancy-associated plasma protein A (PAPP-A) levelssurrogate
Main Result
Absolute Event Rate: 1.58% vs 1.86%
p-value: p=0.03
Calcium channel blocker use is associated with lower levels of PAPP-A in older hypertensive adults, suggesting a potential mechanism for cardiovascular protection.
Limitations
- Findings need to be confirmed in prospective studies
- Cross-sectional design requires confirmation in prospective studies
Cite This Study
Onder et al. (2007) conducted a cross-sectional in Hypertension (n=314). Calcium channel blockers vs. Nonusers was evaluated on Pregnancy-associated plasma protein A (PAPP-A) levels (p=0.03). Calcium channel blocker use was associated with significantly lower PAPP-A levels compared to nonuse among older adults with hypertension (1.58 vs 1.86 mIU/L; p=0.03).