Key result
Bicarbonate dialysis was associated with a significantly lower frequency of ventricular arrhythmias compared to acetate dialysis (32 vs 93 per hour; p<0.005).
Why the study?
Does bicarbonate dialysis reduce the frequency of ventricular arrhythmias compared to acetate dialysis in patients undergoing hemodialysis?
Population
18 patients undergoing hemodialysis, including 5 with ischemic heart disease
Comparison
Bicarbonate dialysis (BHD) vs Acetate dialysis (AHD)
Design
Cohort
Authors
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May support bicarbonate dialysate preference in hemodialysis; leaves open need for randomized confirmation before practice change.
Observational (n=18)
Does bicarbonate dialysis reduce the frequency of ventricular arrhythmias compared to acetate dialysis in patients undergoing hemodialysis?
Absolute Event Rate: 32% vs 93%
p-value: p=<0.005
Bicarbonate dialysis is associated with a significantly lower frequency and severity of ventricular arrhythmias compared to acetate dialysis, possibly due to better correction of acidosis and ionic flows.
Fantuzzi et al. (2008) conducted an observational in Hemodialysis (n=18). Bicarbonate dialysis vs. Acetate dialysis was evaluated on Frequency of ventricular arrhythmias per hour (p=<0.005). Bicarbonate dialysis was associated with a significantly lower frequency of ventricular arrhythmias compared to acetate dialysis (32 vs 93 per hour; p<0.005).
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