Why the study?
Does pretreatment with esmolol or labetalol attenuate hyperdynamic cardiovascular responses in patients with cardiovascular risk factors undergoing electroconvulsive therapy?
Population
18 patients with at least one cardiovascular risk factor treated with electroconvulsive therapy
Comparison
Esmolol or labetalol administered as a bolus… vs No drug pretreatment
Design
RCT, randomized block design
Follow-up
10 minutes after seizure
Authors
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Supports esmolol or labetalol pretreatment to blunt ECT hemodynamic surges in high-risk patients; extends RCT evidence for dose-dependent efficacy without asystole prolongation.
Does pretreatment with esmolol or labetalol attenuate hyperdynamic cardiovascular responses in patients with cardiovascular risk factors undergoing electroconvulsive therapy?
Pretreatment with esmolol or labetalol dose-dependently attenuates the hyperdynamic cardiovascular responses to electroconvulsive therapy without significantly prolonging asystole.
Castelli et al. (1995) studied this question.
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