Population
Murine and human T cell extracts and RNA sequences containing or lacking adenosine-uridine-rich sequence…
Comparison
Phytohemagglutinin and concanavalin A treatment vs Untreated cells or RNA sequences lacking ARE
Design
Preclinical
Authors
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Premature for clinical use in immune disorders; leaves open the proteins' role in GM-CSF mRNA turnover pending in vivo validation.
The study identifies 93 and 94 kDa proteins in murine and human T cells that bind to regulatory sequences upstream of ARE in GM-CSF mRNA, suggesting a role in controlling mRNA turnover.
Bichsel et al. (1997) studied this question.
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