Key result
VEGF165 gene transfer in rats with acute myocardial infarction resulted in an alpha-1-actin to vimentin ratio approximately three times higher than in non-treated groups.
Why the study?
Does VEGF165 gene transfer improve extracellular matrix remodeling in Wistar rats after acute myocardial infarction?
Population
Wistar rats submitted to myocardial infarction via ligation of the left descending artery, classified into…
Comparison
VEGF165 gene transfer treatment vs No VEGF165 treatment
Design
Preclinical
Authors
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May suggest favorable remodeling in rat AMI; leaves open clinical translation of VEGF165 gene therapy.
Does VEGF165 gene transfer improve extracellular matrix remodeling in Wistar rats after acute myocardial infarction?
VEGF165 gene transfer promotes tissue differentiation and may provide a protective effect against adverse extracellular matrix remodeling after acute myocardial infarction in a preclinical model.
Garcia et al. (2015) studied Acute myocardial infarction. VEGF165 gene transfer vs. Non-treated group was evaluated on Expression of extracellular matrix remodeling markers. VEGF165 gene transfer in rats with acute myocardial infarction resulted in an alpha-1-actin to vimentin ratio approximately three times higher than in non-treated groups.