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Ten-fold serial dilutions of the H52 vaccine strain of infectious bronchitis virus were inoculated intravenously into 3-week-old and 10-week-old chickens. The severity of the histological lesions in the kidney was graded and described. The younger birds were much more resistant to the nephritogenic effects of the virus. Although very small doses of virus caused nephritis, no marked dose-related response was demonstrated in either age group.
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Macdonald et al. (1980) studied this question.
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