Key result
Arterial pleomorphic leiomyosarcoma presented initially as cardiac tamponade in two patients, representing a therapeutic challenge due to the impossibility of surgical treatment.
Why the study?
Arterial vascular leiomyosarcoma is an exceptionally rare and frequently fatal neoplasm with few reported cases, posing a therapeutic challenge when surgical treatment cannot be offered.
Case Report (n=2)
Arterial pleomorphic leiomyosarcoma is an exceptionally rare neoplasm that can present initially as cardiac tamponade and represents a significant therapeutic challenge.
Clinicians should consider rare arterial leiomyosarcoma in tamponade differentials; case reports leave optimal management strategies open.
Soft tissue sarcomas represent <1% of all neoplasms. Leiomyosarcomas comprise only 5-7% of cases, and only 2% of these are vascular. Vascular leiomyosarcomas are extremely rare and represent only 0.001% of all neoplasms, the venous type being up to 5 times more frequent. Arterial leiomyosarcomas most frequently affect the great vessels, being fatal in most cases. In the reported cases of arterial leiomyosarcomas, the most frequently affected site is the pulmonary artery. We present the clinical case of 2 patients (a 42-year-old woman and a 36-year-old man) with a diagnosis of arterial pleomorphic leiomyosarcoma that conditioned cardiac tamponade as the initial manifestation. As it is an exceptionally rare neoplasm and with few cases reported in the literature, it is important to identify and describe this pathology which, due to the impossibility of offering surgical treatment, represents a therapeutic challenge.
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Fernández-Ferreira et al. (2021) conducted a case report in Arterial pleomorphic leiomyosarcoma (n=2). Arterial pleomorphic leiomyosarcoma was evaluated. Arterial pleomorphic leiomyosarcoma presented initially as cardiac tamponade in two patients, representing a therapeutic challenge due to the impossibility of surgical treatment.
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