Key result
Daily saline infusion of >500 mL for 3 to 5 days increased the risk of abnormal blood pressure variability compared to <500 mL per day in hypertensive patients.
Why the study?
Excessive saline infusion may increase drug-induced sodium intake, but its effects on blood pressure variability in patients with hypertension remain to be investigated.
Does saline infusion >500 mL per day increase abnormal blood pressure variability in non-critically ill patients with hypertension?
Observational (n=1,010)
No
Does saline infusion >500 mL per day increase abnormal blood pressure variability in non-critically ill patients with hypertension?
Answers are grounded in this paper and cite their sources.
Intravenous saline infusion exceeding 500 mL per day for 3 to 5 days significantly increases the risk of abnormal blood pressure variability in hypertensive patients, highlighting the clinical importance of iatrogenic sodium intake.
Saline is a commonly used intravenous solvent, however, its excessive infusion may increase drug-induced sodium intake. To investigate the effects of saline infusion on blood pressure variability (BPV) in patients with hypertension, a retrospective study was performed in 1010 patients with hypertension. The patients who received saline infusion before surgery for continuous 3 to 5 days were divided into 2 groups according to the saline infusion volume during the hospitalization, which are >500 mL per day group and <500 mL per day group. The overall incidence of abnormal BPV was 11.58%. As for the incidence of abnormal BPV in the <500 mL per day group with 698 patients was 9.17%, while that in the >500 mL per day group with 312 patients was as high as 16.99%. Additionally, >500 mL of daily saline infusion for continuous 3 to 5 days (P for trend = .004, odds ratio [OR] = 1.911, 95% confidence interval [CI] for OR 1.226-2.977), medical history of diabetes mellitus (P < .001, OR = 4.856, 95% CI for OR 3.118-7.563) and cardiovascular diseases (P < .001, OR = 2.498, 95% CI for OR 1.549-4.029) may be risk factors of abnormal BPV; while anti-hypertensive therapy with diuretics (P < .001, OR = 0.055, 95% CI for OR 0.024-0.125) may be the protective factor. Our study suggests that >500 mL of daily saline infusion for continuous 3 to 5 days may have disadvantages in the blood pressure control for hypertensive patients, especially for the patients with diabetes mellitus and cardiovascular diseases.
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Nie et al. (2020) conducted an observational in Hypertension (n=1,010). Saline infusion >500 mL per day vs. Saline infusion <500 mL per day was evaluated on Abnormal blood pressure variability (BPV > 20 mm Hg) (OR 1.911, 95% CI 1.226-2.977, p=0.004). Daily saline infusion of >500 mL for 3 to 5 days increased the risk of abnormal blood pressure variability compared to <500 mL per day in hypertensive patients.
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