Key result
A preoperative ADP test result of < 26 U tripled the risk of major postoperative bleeding complications (OR 3.15) in patients on antiplatelet therapy undergoing coronary artery bypass graft surgery.
Why the study?
Does preoperative multiple electrode platelet aggregometry predict major postoperative bleeding in patients undergoing elective CABG on antiplatelet therapy?
Population
200 consecutive patients referred for elective surgical treatment of stable coronary artery disease…
Design
Cohort
Follow-up
postoperative
Authors
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May support preoperative ADP testing for bleeding risk stratification in CABG; hypothesis-generating and requires prospective validation.
Observational (n=200)
No
Does preoperative multiple electrode platelet aggregometry predict major postoperative bleeding in patients undergoing elective CABG on antiplatelet therapy?
Odds Ratio: 3.15 (95% CI 1.2–8.26)
p-value: p=0.019
Preoperative multiple electrode aggregometry (ADP test < 26 U) can identify patients at increased risk of serious bleeding complications after CABG surgery.
Woźniak et al. (2016) conducted an observational in Stable coronary artery disease (n=200). Preoperative ADP test result < 26 U vs. Preoperative ADP test result ≥ 26 U was evaluated on Composite of perioperative intracranial bleeding within 48h, re-operation for bleeding, transfusion of ≥5 units PRBCs within 48h, or chest tube output ≥2000 ml within 24h (OR 3.15, 95% CI 1.20-8.26, p=0.019). A preoperative ADP test result of < 26 U tripled the risk of major postoperative bleeding complications (OR 3.15) in patients on antiplatelet therapy undergoing coronary artery bypass graft surgery.
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