Key result
Multiplate impedance aggregometry was the only method to demonstrate an acceptable reliability coefficient (R > 0.40) among healthy volunteers and donors on antiplatelet therapy.
Why the study?
Which platelet function test provides the best precision and reliability for monitoring antiplatelet therapy in healthy volunteers and donors?
Population
40 healthy volunteers and 10-13 volunteers on daily aspirin and/or clopidogrel therapy
Comparison
5 platelet function tests vs Comparison among the 5 platelet function tests
Design
Cross-sectional
Authors
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Multiplate may merit further study for platelet monitoring; cross-sectional data leave clinical practice unchanged.
Observational (n=53)
Which platelet function test provides the best precision and reliability for monitoring antiplatelet therapy in healthy volunteers and donors?
Multiplate impedance aggregometry is the most reliable among 5 tested methods for monitoring the effects of antiplatelet agents, while TEG PM is the least suited.
Karon et al. (2014) conducted an observational in Healthy volunteers and donors on antiplatelet therapy (n=53). 5 platelet function tests (LTA, Multiplate, VerifyNow, TEG PM, flow cytometry) was evaluated on Intraassay precision, interassay precision, and reliability coefficient. Multiplate impedance aggregometry was the only method to demonstrate an acceptable reliability coefficient (R > 0.40) among healthy volunteers and donors on antiplatelet therapy.