Maternal Midpregnancy Glucose Levels and Risk of Congenital Heart Disease in Offspring
Key result
Maternal midpregnancy blood glucose levels were strongly associated with increased odds of tetralogy of Fallot in offspring (adjusted OR 7.54; 95% CI, 2.30-24.69).
Why the study?
Do maternal midpregnancy glucose and insulin levels increase the risk of specific congenital heart diseases in offspring?
Population
277 pregnant women in southern and central California carrying infants with tetralogy of Fallot…
Comparison
Maternal midpregnancy measures of glucose and… vs Maternal midpregnancy measures in women carrying…
Design
Case-control
Authors
Discussion
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Implication
Should not yet change prenatal glucose management; leaves open causal links to specific congenital heart defects.
Study Design
Type
Case-Control (n=277)
Structured PICO
Do maternal midpregnancy glucose and insulin levels increase the risk of specific congenital heart diseases in offspring?
P
Population
277 pregnant women from a population-based cohort in California carrying infants with tetralogy of Fallot, dextrotransposition of the great arteries, or healthy infants.
E
Exposure
Maternal midpregnancy measures of glucose and insulin from random nonfasting second-trimester blood samples
C
Comparator
Maternal midpregnancy measures in women carrying healthy infants without congenital heart disease
O
Outcome
Odds of specific cardiac malformations (tetralogy of Fallot or dextrotransposition of the great arteries)hard clinical
Main Result
Odds Ratio: 7.54 (95% CI 2.3–24.69)
Elevated maternal midpregnancy glucose levels are strongly associated with increased odds of tetralogy of Fallot in offspring, suggesting subclinical glucose abnormalities may confer risk for specific congenital heart diseases.
Cite This Study
Priest et al. (2015) conducted a case-control in Congenital heart disease in offspring (n=277). Maternal midpregnancy glucose levels vs. Maternal midpregnancy glucose levels of healthy infants without CHD was evaluated on Odds of tetralogy of Fallot (TOF) (adjusted OR 7.54, 95% CI 2.30-24.69). Maternal midpregnancy blood glucose levels were strongly associated with increased odds of tetralogy of Fallot in offspring (adjusted OR 7.54; 95% CI, 2.30-24.69).