Key result
The AdipoChaser mouse model demonstrated that epididymal fat initiates adipogenesis after prolonged high fat diet, whereas subcutaneous fat primarily undergoes hypertrophy.
The AdipoChaser mouse model reveals distinct developmental timelines and dynamic responses of different white adipose depots to physiological challenges like high fat diet and cold exposure.
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Mouse adipose depot differences urge clinical caution in extrapolation; leaves open human translation and mechanisms.
Wang et al. (2014) studied Adipogenesis and obesity. High fat diet, cold exposure, and β-3 agonist stimulation was evaluated on Adipogenesis and adipocyte turnover in different fat depots. The AdipoChaser mouse model demonstrated that epididymal fat initiates adipogenesis after prolonged high fat diet, whereas subcutaneous fat primarily undergoes hypertrophy.
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