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November 1, 1990Coronary Artery Disease

Hyperhomocyst(e)inemia in Utah siblings with early coronary disease

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Why the study?

Is plasma homocyst(e)ine level an independent risk factor and inherited abnormality associated with early familial coronary heart disease?

Population

85 participants including 37 with early familial coronary heart disease and 48 age- and sex-matched controls…

Comparison

Elevated plasma homocyst(e)ine (H(e)) levels vs Age- and sex-matched control subjects

Design

Case-control

Authors

RWRoger R. WilliamsNational Heart Lung and Blood InstituteMMM.R. MalinowUnion CollegeSHSteven C. HuntUniversity of Utah

Discussion

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Implication

Supports homocysteine as potential inherited marker in early familial CHD; observational data leave causal role and therapeutic implications open.

Structured PICO

Is plasma homocyst(e)ine level an independent risk factor and inherited abnormality associated with early familial coronary heart disease?

P
Population
85 participants including 37 with early familial coronary heart disease (EFCHD) (33 men, 4 women) and 48 age- and sex-matched controls (30 men, 18 women) from the University of Utah Cardiovascular Genetics Research Clinic. The cohort included 13 male sibling pairs with EFCHD, 13 male sibling pairs as controls, and 13 spouse pairs as controls.
I
Intervention
Elevated plasma homocyst(e)ine (H(e)) levels
C
Comparator
Age- and sex-matched control subjects
O
Outcome
Plasma homocyst(e)ine levels in EFCHD cases versus controls and familial correlation of H(e) levelssurrogate

Hyperhomocyst(e)inemia is an independent predictor and inherited abnormality that may explain some occurrences of early familial coronary heart disease.

Cite This Study

Williams et al. (1990) studied this question.

synapsesocial.com/papers/6a961ded538affa4349fea09https://doi.org/10.1097/00019501-199011000-00008
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Echocardiographic assessment of the relationship between cardiac function and plasma homocysteine levels in patients with heart failure and preserved ejection fraction2025 · 4 citations
  2. 2Homocysteine Levels Are Associated with Increased Risk of Congestive Heart Failure in Patients with and without Coronary Artery Disease2006 · 21 citations
  3. 3Genetic and environmental factors affecting the incidence of coronary artery disease in heterozygous familial hypercholesterolemia.1991 · 175 citations
  4. 4Homocysteine in Chronic Heart Failure2015 · 27 citations
  5. 5Hyperhomocyst(e)inemia Is a Risk Factor for Arterial Endothelial Dysfunction in Humans1997 · 490 citations