Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
March 10, 2025Frontiers in Cardiovascular MedicineOpen Access

Echocardiographic assessment of the relationship between cardiac function and plasma homocysteine levels in patients with heart failure and preserved ejection fraction

View Full Paper
Ask AI
Bookmark
Share

Why the study?

The role of plasma homocysteine levels in HFpEF has been understudied, despite elevated levels being known to affect cardiovascular health.

Population

80 HFpEF patients and 80 matched controls without HFpEF

Comparison

HFpEF patients vs matched controls without HFpEF

Design

Retrospective observational study

Authors

ZXZ L XieFudan UniversityQXQing XieShanxi Agricultural UniversityXWXiaojuan WuNorthwest University

Discussion

Loading...

Member takes

Implication

May flag more remodeling in HFpEF but should not yet change practice; leaves open Hcy as causal target.

Structured PICO

P
Population
80 patients with heart failure with preserved ejection fraction (HFpEF) and 80 matched controls without HFpEF
C
Comparator
80 matched controls without HFpEF
O
Outcome
Plasma homocysteine (Hcy) levels and echocardiographic parameters (IVST, LVPWT, LAD, LVEDD, LVEF, E/A ratio)surrogate

Elevated plasma homocysteine is associated with myocardial remodeling and impaired diastolic function in HFpEF patients, highlighting its potential as a biomarker for disease severity.

Cite This Study

Xie et al. (2025) studied this question.

synapsesocial.com/papers/6a7fbcfefeefc34aa44224a2https://doi.org/10.3389/fcvm.2025.1525389
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Homocysteine Levels in Patients with Heart Failure with Preserved Ejection Fraction2010 · 28 citations
  2. 2How to diagnose heart failure with preserved ejection fraction: the HFA–PEFF diagnostic algorithm: a consensus recommendation from the Heart Failure Association (HFA) of the European Society of Cardiology (ESC)2019 · 1,887 citations
  3. 3The metabolism and significance of homocysteine in nutrition and health2017 · 384 citations
  4. 4ACC/AHA Versus ESC/ESH on Hypertension Guidelines2019 · 327 citations
  5. 5Heart Failure with Preserved Ejection Fraction: Mechanisms and Treatment Strategies2021 · 231 citations