Elevated homocysteine levels were associated with a 3.8% increased odds of reduced ejection fraction (<55%) in pediatric myocarditis patients (OR 1.038, 95% CI 1.003-1.074, P=0.033).
Cross-Sectional (n=164)
No
Are elevated homocysteine levels associated with reduced ejection fraction in pediatric patients with myocarditis?
Elevated plasma homocysteine levels are associated with an increased risk of reduced ejection fraction (<55%) in pediatric patients with myocarditis, particularly in males and overweight individuals.
Effect estimate: OR 1.038 (95% CI 1.003-1.074)
Absolute Event Rate: 31% vs 69%
p-value: p=0.033
Background The relationship between homocysteine (HCY) and ejection fraction (EF) has been demonstrated in diseases such as coronary artery disease, but the relationship between HCY and EF in pediatric patients with myocarditis remains unclear. The aim of this study was to investigate the relationship between HCY and EF in pediatric patients with myocarditis. Methods This single-center cross-sectional study included 164 pediatric myocarditis patients aged 1–18 years, including 104 males and 60 females, at Anzhen Hospital (2023–2024) in Beijing. Patient demographic characteristics were collected, and blood tests were performed to assess HCY, routine blood tests, and markers of myocardial damage. EF was measured using 3.0T cardiac magnetic resonance (CMR), and patients were grouped using EF 55% as the cutoff value. Statistical analyses were performed using t-tests, Binary logistic regression and Restrict cubic spline (RCS), and subgroup analyses age, sex, body mass index (BMI). Results Of the 164 patients, 31% ( n = 51) had EF values 55%. High HCY concentration demonstrated a statistically positive relationship with the risk of occurrence of EF 55% (OR = 1.033, P = 0.034). Subgroup analysis showed a stronger correlation in men (OR = 1.045, P = 0.016) and in those with a BMI ≥ 24 kg/m 2 (OR = 1.083, P = 0.010). The RCS showed a non-significant trend of increasing EF 55% ( P 0.05). Conclusion The findings suggest that elevated HCY levels are a risk factor for EF 55% in pediatric patients with myocarditis, especially in males and overweight individuals.
Zhang et al. (Wed,) conducted a cross-sectional in pediatric myocarditis (n=164). Elevated homocysteine levels vs. Lower/normal homocysteine levels was evaluated on Risk of reduced ejection fraction (EF < 55%) assessed by cardiac magnetic resonance (CMR) (OR 1.038, 95% CI 1.003-1.074, p=0.033). Elevated homocysteine levels were associated with a 3.8% increased odds of reduced ejection fraction (<55%) in pediatric myocarditis patients (OR 1.038, 95% CI 1.003-1.074, P=0.033).