Key result
HFpEF is linked to ~66% higher fasting homocysteine levels than healthy controls.
Why the study?
Are homocysteine levels elevated in patients with heart failure with preserved ejection fraction compared to healthy controls?
Population
68 patients hospitalized for symptomatic heart failure with preserved LVEF and 40 age- and sex-matched…
Design
Cross-sectional
Authors
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Hyperhomocysteinemia may mark HFpEF severity; extends cross-sectional data but leaves open causal and therapeutic implications.
Case-Control (n=108)
Are homocysteine levels elevated in patients with heart failure with preserved ejection fraction compared to healthy controls?
Absolute Event Rate: 16.9% vs 10.15%
p-value: p=<0.001
Hyperhomocysteinemia is prevalent in patients with heart failure with preserved ejection fraction and is independently associated with NT-proBNP, hs-CRP, E/A ratio, and HbA1C.
Okuyan et al. (2010) conducted a case-control in Heart failure with preserved ejection fraction (n=108). Heart failure with preserved ejection fraction vs. Healthy controls was evaluated on Total fasting homocysteine concentrations (p=<0.001). Patients with heart failure with preserved ejection fraction had significantly higher mean total fasting homocysteine concentrations compared to healthy controls (16.9 vs. 10.15 μmol/l; p < 0.001).
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