August 28, 2006Cardiology
Homocysteine Levels Are Associated with Increased Risk of Congestive Heart Failure in Patients with and without Coronary Artery Disease
Why the study?
Do high homocysteine levels predict left ventricular dysfunction or clinical congestive heart failure in patients undergoing coronary angiography?
Population
2,842 patients undergoing coronary angiography, mean age 64 +/- 12 years, 69% men, 74% with CAD.
Comparison
High homocysteine levels vs Low homocysteine levels
Design
Cohort
Authors
Discussion
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Member takes
Implication
Does not support practice change from homocysteine measurement; leaves open causal role and need for interventional trials in LVD.
Structured PICO
Do high homocysteine levels predict left ventricular dysfunction or clinical congestive heart failure in patients undergoing coronary angiography?
P
Population
2,842 patients undergoing coronary angiography, mean age 64 +/- 12 years, 69% men, 74% with CAD.
I
Intervention
High homocysteine levels (Quartile 3: 13.3-17.0 micromol/l and Quartile 4: >=17.1 micromol/l)
C
Comparator
Low homocysteine levels (Quartile 1: <=10.5 micromol/l)
O
Outcome
Left ventricular dysfunction (LVD, defined as ejection fraction <=40%) or combination of LVD and clinical congestive heart failure (CHF)composite
High homocysteine levels are independently associated with an increased risk of left ventricular dysfunction and clinical congestive heart failure, regardless of underlying coronary artery disease.
Cite This Study
May et al. (2006) studied this question.