Why the study?
How do serum NT-proBNP levels change before and after surgery in young children with congestive heart failure secondary to congenital heart malformations compared to healthy controls?
Observational (n=35)
How do serum NT-proBNP levels change before and after surgery in young children with congestive heart failure secondary to congenital heart malformations compared to healthy controls?
p-value: p=<0.001
NT-proBNP levels are significantly elevated in young children with CHF secondary to congenital heart malformations and increase further in the immediate 24-hour post-operative period.
Supports perioperative biomarker monitoring in pediatric congenital heart disease; hypothesis-generating and requires prospective validation before clinical adoption.
OBJECTIVE: We measured serum NT-proBNP levels in 2 groups of young patients (0-36 months) with congestive heart failure (CHF) secondary to congenital heart malformations (CHM). METHODS: The first group included 23 patients prior to surgery for heart malformations. The second group included 12 patients with CHM within 24 hours post-operation. NT-proBNP levels were measured by an enzyme-linked immunosorbent immunoassay (ELISA) using the Chem Well 2910 (Awareness Technology Inc.) automated analyzer. RESULTS: NT-proBNP values were 4 times higher in patients with unoperated CHM compared to healthy controls (P < 0.001), and 12 times higher in patients with CHM 24 hours after surgery compared to controls (P = 0.0001). CONCLUSIONS: These results demonstrated significant changes in NT-proBNP concentrations before and after surgery to correct congenital heart malformations.
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Butnariu et al. (2014) conducted an observational in Congestive heart failure secondary to congenital heart malformations (n=35). Congenital heart malformations (pre- and post-surgery) vs. Healthy controls was evaluated on Serum NT-proBNP levels (p=<0.001).
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