Key result
Stent implantation resulted in more intense and sustained expression of MMP9 and activation of MMP2 than balloon angioplasty (P=0.002).
Why the study?
Does stent implantation compared to balloon angioplasty alter the expression of matrix metalloproteinases in hypercholesterolemic rabbits?
Does stent implantation compared to balloon angioplasty alter the expression of matrix metalloproteinases in hypercholesterolemic rabbits?
p-value: p=0.002
Stent implantation induces a more intense and sustained expression of MMP9 and activation of MMP2 compared to balloon angioplasty, which may contribute to more severe intimal growth and in-stent restenosis.
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Stent-induced MMP upregulation may drive restenosis in hypercholesterolemic models; leaves open whether MMP inhibition reduces human in-stent restenosis.
Feldman et al. (2001) studied Hypercholesterolemia. Stent implantation vs. Balloon angioplasty was evaluated on Expression of MMP9 and MMP2 (p=0.002). Stent implantation resulted in more intense and sustained expression of MMP9 and activation of MMP2 than balloon angioplasty (P=0.002).
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