Why the study?
Does hexobendine potentiate the coronary vasodilator metabolite released by cardiac stimulation or hypoxia in isolated guinea-pig hearts?
Population
Isolated guinea-pig hearts
Comparison
Hexobendine infusion during cardiac stimulation vs Exogenous adenosine or baseline responses…
Design
Preclinical
Authors
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Questions adenosine as coronary vasodilator metabolite in guinea-pig hearts; leaves open its identity and relevance to other models.
Does hexobendine potentiate the coronary vasodilator metabolite released by cardiac stimulation or hypoxia in isolated guinea-pig hearts?
The study provides evidence that the coronary vasodilator metabolite released by catecholamines, histamine, and hypoxia in guinea-pig hearts is not adenosine.
Rothaul et al. (1981) studied this question.
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