Answers are grounded in this paper and cite their sources.
Total synthesis of novel DMT-phosphoramidites of thymidine (11 and 15) and 2′-deoxyguanosine (8 and 20) have been accomplished. The utility of these modified building blocks in the preparation of triple helix forming oligodeoxyribonucleotides with a stretched phosphodiester backbone has been evaluated. It was found that the oligonucleotides with extended backbones were unable to enhance the binding to duplex targets containing CG or TA base pairs.
No takes yet. Share an insight, caveat, or question.
Rao et al. (1994) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: