Key result
A 1-year change in diastolic blood pressure was independently associated with an increased risk of aortic disease-related death in a general Japanese population, with a hazard ratio of 1.084 per 1-mmHg increase.
Why the study?
While hypertension is associated with aortic disease development, it remained unclear whether a 1-year change in diastolic blood pressure is a risk factor for aortic disease-related mortality in the general population.
Is a 1-year change in diastolic blood pressure associated with aortic disease-related mortality in a general population aged 50-75 years?
Cohort (n=235,076)
Yes
Is a 1-year change in diastolic blood pressure associated with aortic disease-related mortality in a general population aged 50-75 years?
Answers are grounded in this paper and cite their sources.
A 1-year change in diastolic blood pressure is significantly associated with aortic disease-related mortality in the general population aged 50-75 years, highlighting the importance of DBP monitoring.
BACKGROUND: Aortic diseases (ADs), including aortic dissection, aortic aneurysm, and aortic rupture, are fatal diseases with extremely high mortality rates. Hypertension has been reported to be associated with AD development; however, it remains unclear whether a 1-year change in diastolic blood pressure (DBP) is a risk factor for AD-related mortality in the general population. METHODS AND RESULTS: This study used a nationwide database of 235,076 individuals (aged 50-75 years) who participated in the annual "Specific Health Check and Guidance in Japan" for 2 consecutive years between 2008 and 2010. There were 55 AD-related deaths during the follow-up period of 1,770 days. All subjects were divided into 4 groups based on the baseline DBP and change in DBP at 1 year: persistent high DBP, increasing DBP, decreasing DBP, and normal DBP. Kaplan-Meier analysis demonstrated that the persistent high DBP group had the greatest risk among the 4 groups. Multivariate Cox proportional hazard regression analysis demonstrated that both DBP and 1-year change in DBP were significantly associated with AD-related deaths. The prediction capacity was significantly improved by the addition of 1-year change in DBP to confounding risk factors. CONCLUSIONS: This study demonstrated for the first time that a 1-year change in DBP was associated with AD-related deaths in the general population. Monitoring changes in DBP are of critical importance in the primary prevention of AD-related deaths in apparently healthy subjects aged 50-75 years.
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A 2021 study conducted a cohort in Aortic disease-related mortality (n=235,076). 1-year change in diastolic blood pressure vs. Baseline diastolic blood pressure was evaluated on Aortic disease-related death (HR 1.084, 95% CI 1.054-1.115, p=<0.0001). A 1-year change in diastolic blood pressure was independently associated with an increased risk of aortic disease-related death in a general Japanese population, with a hazard ratio of 1.084 per 1-mmHg increase.
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