Key result
Elevated cardiac troponin I and T levels on admission were significantly associated with mortality in multiple trauma patients, independent of age, vital signs, and GCS score (OR 0.6).
Why the study?
The relationship between increased cardiac troponin levels and morbidity and mortality in traumatic patients is not well recognized.
Does elevated cardiac troponin I and T on admission predict mortality in multiple trauma patients?
Cohort (n=400)
No
Does elevated cardiac troponin I and T on admission predict mortality in multiple trauma patients?
Odds Ratio: 0.6 (95% CI 0.4–1)
p-value: p=<0.05
Elevated cardiac troponin I and T levels on admission provide independent prognostic information regarding mortality in multiple-trauma patients.
May aid mortality risk stratification in trauma patients; hypothesis-generating and requires prospective validation before clinical use.
INTRODUCTION: The relationship between increased levels of cardiac troponins and morbidity and mortality of traumatic patients is not still well recognized. AIM: The aim of this study was to investigate the prognostic value of cardiac troponin I and T on admission in mortality of multiple trauma patients admitted to the emergency department. METHODS: In this prospective follow-up study, the cardiac troponin I and T levels were measured in patients with multiple trauma referring to the emergency department (ED) between March 2014 and February 2015 at Imam Khomeini Hospital, Sari, Iran. Patients were followed prospectively until discharge from hospital or death. RESULTS: The levels of cardiac troponins I and T in patients with multiple trauma were significantly associated with their mortality, especially at the level of 0.5 and 1.2 μg/dl (p<0.05). Multivariate regression analysis showed association of level of cardiac troponin I and T with patients' mortality, after controlling for patients' age, vital signs and GCS on admission. The sensitivity and specificity of troponin I at levels greater than 0.4 μg/dl in predict mortality in this study were as 65.5% and 55.3%, while the values for troponin T were 65.1% and 54.9%, respectively. CONCLUSION: Elevated cardiac troponin I and T levels provide excellent prognostic information regarding mortality in patients with multiple-trauma, independent of age, hemodynamic variables and GCS score.
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Montazer et al. (2019) conducted a cohort in Multiple trauma (n=400). Elevated cardiac troponin I and T levels vs. Normal cardiac troponin levels was evaluated on Mortality (OR 0.6, 95% CI 0.4-1.0, p=<0.05). Elevated cardiac troponin I and T levels on admission were significantly associated with mortality in multiple trauma patients, independent of age, vital signs, and GCS score (OR 0.6).
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