Key result
The riser blood pressure pattern, an abnormal circadian rhythm, was independently associated with heart failure with preserved ejection fraction (OR 1.73).
Cross-Sectional (n=508)
Yes
Odds Ratio: 1.73 (95% CI 1.02–2.91)
p-value: p=0.041
Riser BP pattern associated with HFpEF; hypothesis-generating for nocturnal BP monitoring, prospective trials needed before practice change.
Paradoxical increase in blood pressure (BP) during sleep, exceeding those of awake BP, is called the "riser" BP pattern, and known as an abnormal circadian BP rhythm, has been reported to be associated with adverse cardiovascular prognoses. However, the significance of ambulatory BP in heart failure patients with preserved ejection fraction (HFpEF) has never been reported. Here, we tested our hypothesis that abnormal circadian BP rhythm is associated with HFpEF. The authors enrolled 508 patients with hospitalized HF (age 68±13 years; 315 men, 193 women). There were 232 cases of HFpEF and 276 cases of heart failure with reduced ejection fraction (HFrEF). The riser BP pattern was significantly more frequent in the HFpEF (28.9%) group compared with the HFrEF group (19.9%). In a multivariable logistic regression analysis, the riser BP pattern was associated with HFpEF (odds ratio, 1.73; 95% confidence interval, 1.02-2.91; P=.041) independent of the other covariates. In conclusion, the riser BP pattern was associated with HFpEF.
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Komori et al. (2016) conducted a cross-sectional in Heart Failure (n=508). Riser blood pressure pattern vs. Non-riser blood pressure pattern was evaluated on Heart failure with preserved ejection fraction (HFpEF) (OR 1.73, 95% CI 1.02-2.91, p=0.041). The riser blood pressure pattern, an abnormal circadian rhythm, was independently associated with heart failure with preserved ejection fraction (OR 1.73).
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