Key result
Prediabetes is associated with higher adipose tissue dietary fatty acid trapping, which offsets the increased appearance rate of palmitate from intracellular lipolysis.
Observational
Enhanced dietary fatty acid trapping in adipose tissue serves as a protective adaptive mechanism against excess obesity-related palmitate appearance in prediabetes.
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May buffer lipotoxicity in prediabetes; hypothesis-generating for adipose-targeted interventions.
We found higher adipose tissue dietary fatty acid trapping, limiting spillover to lean organs, that in part offsets the increase in appearance rate of palmitate from intracellular lipolysis in prediabetes. These results point to the adaptive nature of adipose tissue trapping and dietary fatty acid spillover as a protective mechanism against excess obesity-related palmitate appearance rate from intracellular adipose tissue lipolysis.
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Montastier et al. (2021) conducted an observational in Prediabetes. Prediabetes was evaluated on Adipose tissue dietary fatty acid trapping and palmitate appearance rate. Prediabetes is associated with higher adipose tissue dietary fatty acid trapping, which offsets the increased appearance rate of palmitate from intracellular lipolysis.
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