Key result
Prediabetes is associated with impaired storage of dietary fatty acids in abdominal adipose tissue and increased channeling toward the heart, which is linked to reduced cardiac function.
Prediabetes is associated with abnormal dietary fatty acid partitioning, including increased channeling to the heart which correlates with subclinical cardiac dysfunction.
Should not yet change practice; extends metabolic observations to cardiac effects but remains hypothesis-generating.
PURPOSE OF REVIEW: Experimental evidences are strong for a role of long-chain saturated fatty acids in the development of insulin resistance and type 2 diabetes. Ectopic accretion of triglycerides in lean organs is a characteristic of prediabetes and type 2 diabetes and has been linked to end-organ complications. The contribution of disordered dietary fatty acid (DFA) metabolism to lean organ overexposure and lipotoxicity is still unclear, however. DFA metabolism is very complex and very difficult to study in vivo in humans. RECENT FINDINGS: We have recently developed a novel imaging method using PET with oral administration of 14-R,S-F-fluoro-6-thia-heptadecanoic acid (FTHA) to quantify organ-specific DFA partitioning. Our studies thus far confirmed impaired storage of DFA per volume of fat mass in abdominal adipose tissues of individuals with prediabetes. They also highlighted the increased channeling of DFA toward the heart, associated with subclinical reduction in cardiac systolic and diastolic function in individuals with prediabetes. SUMMARY: In the present review, we summarize previous work on DFA metabolism in healthy and prediabetic states and discuss these in the light of our novel findings using PET imaging of DFA metabolism. We herein provide an integrated view of abnormal organ-specific DFA partitioning in prediabetes in humans.
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Noll et al. (2016) conducted a review in Prediabetes. Dietary fatty acid (DFA) metabolism vs. Healthy state was evaluated. Prediabetes is associated with impaired storage of dietary fatty acids in abdominal adipose tissue and increased channeling toward the heart, which is linked to reduced cardiac function.
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